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Allergy and Airway: Asthma IV |

The Pathologic Changes of Small Airway in a Neutrophilic Asthma Mouse Model

Wenjin Sun; Xudong Xiang, MD
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The Second Xiangya Hospital Of Central South University, Changsha, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A40. doi:10.1016/j.chest.2016.02.042
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SESSION TITLE: Asthma IV

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: To investigate the pathologic changes of small airway in a neutrophilic asthma mouse model

METHODS: Ovalbumin (OVA) and house dust mites (HDM) were applied for sensitization to establish the neutrophilic asthma mouse model, Airway hyperresponsiveness (AHR) was evaluated at 24 h after the last airway challenge. The subtypes and numbers of inflammatory cells in bronchoalveolar lavage fluid (BALF) were counted. Based on small airways (D<500μm) and larger airways (D>500μm), the pathological changes of lung tissues were observed by HE staining, immunohistochemistry of neutrophils, eosinophils, IL-4 and IL-17.

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