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Allergy and Airway: Asthma IV |

Programmed Vaccination May Increase the Prevalence of Asthma and Allergic Diseases FREE TO VIEW

Zhuang Ma, PhD
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General Hospital of Shenyang Military Command, Shenyang, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A38. doi:10.1016/j.chest.2016.02.040
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Published online

SESSION TITLE: Asthma IV

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: The prevalence of asthma and allergic diseases has risen in recent decades. The etiology of asthma and allergic diseases has not been entirely elucidated. In this paper, we investigated the possibility that programmed vaccination in China may have a potential role in asthma and allergic diseases.

METHODS: Newborn BALB/C mice were randomly divided into three groups: vaccine plus OVA, OVA and control group. The mice of vaccine plus OVA group was inoculated with vaccines following the National Vaccines Inoculation Program in China. Mice of vaccine plus OVA and OVA groups were sensitized and challenged with OVA. Lung function was assessed and serum IL-4 and IFN-γwere measured.

RESULTS: The results of lung function showed that mice of vaccine plus OVA group exhibited a increase in Penh compared to that in OVA group at Methacholine concentrations of 6.25 and 12.5 mg/ml (P<0.05). Serum IL-4 in the vaccine plus OVA group was higher than that in the OVA group (P<0.01). Serum IFN-γ in the OVA group was less than that in the control group (P<0.01), and also less than that in the vaccine plus OVA group (P<0.05). The ratio of IFN-γ to IL-4 both in the OVA and vaccine plus OVA group was less than that in the control (P<0.01).

CONCLUSIONS: Our study suggested that programmed vaccination in China may have a potential role in the prevalence of asthma and allergic diseases by inducing Th2 cytokine expression and may be responsible for the increasing prevalence of asthma and allergic diseases in China.

CLINICAL IMPLICATIONS: In this study, we put forward a new possible pathogeneisis that vaccines inoculation may increaee the prevalence of asthma and allergic diseases by inducing Th2 cytokine expression. The further study remains to be needed to demonstrate that this mechanism also work in human being and to find a resolution for it.

DISCLOSURE: The following authors have nothing to disclose: Zhuang Ma

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