Allergy and Airway: Asthma IV |

Cerebral Structural Changes Mediate Lung Function Variations in Asthma FREE TO VIEW

Ting Wang; Yu-Chao Jiang; Zong-An Liang; Xing-Yu Xiong; Yu-Lin Ji; Cheng Luo; De-Zhong Yao
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West China Hospital, Sichuan University, Chengdu, China

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A37. doi:10.1016/j.chest.2016.02.039
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SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: Asthma is associated with impairment in neuropsychologic function, and abnormalities in the regulation of autonomic nervous system or neuroendocrine function may contribute to related symptoms. However, little is known about the neural system correlated with asthma. This study aimed to investigate the brain structure changes potential associated with the alterations of lung function and inflammatory markers in asthma.

METHODS: By using magnetic resonance imaging in combination with voxel-based morphomethy, gray matter volumes (GMV) across the whole brain were compared between patients with asthma and healthy controls. Correlation analyses were performed to obtain the neural association with lung function and eosinophils.

RESULTS: The results showed that asthma was positively correlated with the GMV in the right lateral occipital lobe, left rostral middle frontal gyrus, right superior temporal gyrus, and right supplementary motor area. Correlation analyses revealed that the GMV in the right parahippocampal gyrus, left anterior cingulate cortex (ACC), left dorsolateral prefrontal cortex (DLPFC), left oblongata and right pons, and pars triangularis cortex (PTC) was associated with lung function (FVC, FVC%, and FEV1/FVC%); the GMV in the bilateral superior orbitofrontal cortex and middle frontal gyrus was associated with proportion of eosinophils.

CONCLUSIONS: In conclusion, our findings provide preliminary evidence for neuroanatomical correlation of asthma.

CLINICAL IMPLICATIONS: There is neuroanatomical correlates of asthma. The GMV in the parahippocampal gyrus, ACC, DLPFC, oblongata, pons and PTC were associated with lung function alterations in asthma patients. The association between the GMV and lung function provided potential biomarkers for the early detection of lung function alterations in asthma.

DISCLOSURE: The following authors have nothing to disclose: Ting Wang, Yu-Chao Jiang, Zong-An Liang, Xing-Yu Xiong, Yu-Lin Ji, Cheng Luo, De-Zhong Yao

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