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Allergy and Airway: Asthma IV |

Relief of Asthma With Regulatory Cells Associated IL-10 and TGF-β

Jing Liu, PhD
Author and Funding Information

The Second Hospital of Jilin University, Changchun, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A35. doi:10.1016/j.chest.2016.02.037
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SESSION TITLE: Asthma IV

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: To observe the effect of regulatory cells associated IL-10 and TGF-β on asthma.

METHODS: BABL/c mice were immunized with OVA and alums to induce asthma model. On the provocation process, rhIL-10, rhTGF-β, and rhIL-10+rhTGF-β were given by nose drops from 21 to 28 days. We observed the safety and condition of asthma onset on 28d after inspiration and then did bronchoavleolar lavage to collect lavage fluid, which were used to test the concentration of IL-4, INF-γ and IgE as in serum. The lung tissues were left for pathological examination with HE staining and FOXP3 expression testing with Western blot and rt-PCR.

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