Allergy and Airway: Asthma III |

The Sensitization Model and Correlation of Bermuda Grass and Timothy Grass Pollen Allergen in Respiratory Allergic Diseases Patients in Southern China FREE TO VIEW

Wenting Luo; Baoqing Sun
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National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Diseases, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A33. doi:10.1016/j.chest.2016.02.035
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SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: Study on the sensitization model and correlation of bermuda and timothy grass allergen in allergic patients in Southern China.

METHODS: 258 cases of patients with allergic diseases, including 92 asthma patients, 78 allergic rhinitis patients, 88 rhinitis with asthma. Serum sIgE of bermuda, timothy and Japanese hop were detected by UnitCAP. If the bermuda-sIgE were positive, sIgE of Cyn d1, Phl p1, Phl p4, peanut, Ara h1, Ara h8, birch, Bet v1 and CCD were tested.

RESULTS: The sensitization rate of bermuda, timothy and Japanese hop in 258 patients were 22.5%, 13.6% and 7.0% respectively. 53.4% (31/58) bermuda sIgE-positive patients were sensitized to Cyn d1. 100% (35/35) timothy-positive patients were sensitized to Phl p4, but only 17.1% (6/35) were positive to Phl p1. 41.4% of Bermuda-sIgE-positive patients were Japanese hop sIgE-positive. 56.9% (33/58) bermuda-positive patients were sensitized to peanut. Ara h1 were positive in 3 patients. 32.8% (19/18) were sensitized to birch. 6 patients were sensitized to Bet v4 and Ara h8 simultaneously. 39.7% (23/58) bermuda-positive patients with CCD sensitization, and CCD sIgE levels correlated well with bermuda, Cyn d1, timothy and Phl p 4, peanut, birch (P<0.01).

CONCLUSIONS: The sensitization rate of bermuda, timothy and Japanese hop were 22.5%, 13.6% and 7.0% in Southern China. Bermuda sIgE-positive patients were sensitized to timothy, peanuts, CCD and birch and Japanese hop in different degree. Phl p4 was the main component of timothy. CCD had good correlations with grass pollen, peanut and birch allergens, indicated wide cross-reactions between them were caused by carbohydrate cross-react determinants.

CLINICAL IMPLICATIONS: This study was investigated the grass pollen sensitizing apattern of the patients with respiratory allergic diseases in south China, for the first time found that the grass pollen allergens sensitization rates were not low in the south China. It will provide scientific and effective advices for clinical diagnosis and treatment of the respiratory allergic diseases.

DISCLOSURE: The following authors have nothing to disclose: Wenting Luo, Baoqing Sun

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