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Allergy and Airway: Asthma III |

Oxidative Stress Impairs Glucocorticoids Sensitivity of Allergic Asthma Animal Model

Aihua Bao, PhD; Xin Zhou, MD
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Shanghai Jiao Tong University, Shanghai First People's Hospital, Shanghai, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A32. doi:10.1016/j.chest.2016.02.034
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SESSION TITLE: Asthma III

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: To observe the influence of ozone inhalation on the typical therapeutic effects of glucocorticoids and further to explore the involvements of p38MAPK activation and MKP-1 expression upon a mouse asthma model.

METHODS: Mice were sensitized and challenged with ovalbumin (OVA), dexamethasone were administrated ip 1 hr before each challenge (day24,25,26). Ozone expsoure (1.0 ppm 2hr) were performed on day 23, 25 and 27, and SB239063 were injected 1hr before and 4hr after each exposure. Enhanced pause (Penh) were measured at day 28 and followed by bronchoalveolar lavage (BAL). Lung tissues were collected for analysis of expression of inflammatory genes, MKP-1 and p38MAPK.

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