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Allergy and Airway: Asthma III |

Induction of Granulocyte Apoptosis by Bcl-2 Inhibitors Reduces Steroid-Insensitive Airway Inflammation

Bao-ping Tian, PhD; Li-xia Xia, PhD; Zhengqiang Bao, PhD; Wen Li, MD; Zhihua Chen, PhD; Songmin Ying, PhD; Huahao Shen, MD
Author and Funding Information

Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A31. doi:10.1016/j.chest.2016.02.033
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SESSION TITLE: Asthma III

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: Asthmatic inflammation is dominated either by eosinophil or neutrophil accumulation in airways. Resolution of these inflammatory cells is the key to disease alleviation. It is well accepted that eosinophilic airway inflammation is responsive to corticosteroid treatment, while neutrophilic inflammation contributes to most of the corticosteroid-insensitive severe asthma and increases the burden of global health care. Here, we explored a new strategy of effective treatment against corticosteroid-insensitive neutrophilic asthma by small molecule inhibitors against anti-apoptotic protein Bcl-2.

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