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Allergy and Airway: Asthma III |

Intranasal Administration of IL-27 Pre-OVA Sensitization Alleviate Allergic Airway Inflammation in Mice Model

Zhihong Chen, MD; Xiaoqiong Su, MA; Nian Dong, MA; Kan Xu, MA; Xiangdong Wang, MD
Author and Funding Information

Zhongshan Hospital, Shanghai, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A29. doi:10.1016/j.chest.2016.02.031
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SESSION TITLE: Asthma III

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: IL-27 is a family member of Th1 type cytokines, which could promote Th1 development and inhibit Th2 and Th17 development as well. Asthma is Th2-prone chronic airway inflammation. In this study, animal models were set up to observe whether IL-27 intervention could diminish allergic airway inflammation and to investigate the related molecular mechanisms.

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