State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical College, Guangzhou Institute of Respiratory Diseases, Guangzhou, China
Copyright 2016, American College of Chest Physicians. All Rights Reserved.
SESSION TITLE: Asthma III
SESSION TYPE: Original Investigation Poster
PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM
PURPOSE: The aim of the study was to investigate regulation of neurogenic airway inflammation via the dorsal vagal complex (DVC).
METHODS: Neuronal activity in the DVC and transmitter expression as well as its effects on regulation of airway inflammation were observed in a guinea pig model of GER. The effects of DVC on SP expression and microvascular leakage of airway were measured using a stereotaxic technique combined with microinjection to change the activities of neurons or SP concentration in the target area. The pseudorabies virus Bartha (PRV Bartha) was used as a retrograde tracer to examine the pathway from DVC to airway.
RESULTS: Chronic hydrochloric acid (HCl) perfusion into the lower esophagus induced plasm leakage and neuropeptide release in lung. SP and Fos expressions were increased in the nucleus of the solitary tract (nTS) and dorsal motor nucleus of the vagus (DMV). SP expression and microvascular leakage in the airway changed in accordance with neuronal excitability or the SP concentration in the DVC. PRV-infected neurons were distributed in the nTS and the DMV, and about 40% of these were positive for SP.
CONCLUSIONS: CNS is involved in the esophageal-bronchial reflex and neurogenic airway inflammation can be regulated by DVC, which provide a new insight for the treatment of refractory cough and severe asthma.
CLINICAL IMPLICATIONS: The airway neurogenic inflammation may be regulated by DVC, which provides a new therapeutic target in the pathway from airway to CNS, especially refractory cough and severe asthma
DISCLOSURE: The following authors have nothing to disclose: Zhe Chen, Le-jia Sun, Hui Chen, Da-chuan Gu, Wei-tao Zhang, Rong Dong, KeFang Lai
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