SESSION TITLE: Asthma III
SESSION TYPE: Original Investigation Poster
PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM
PURPOSE: The aim of the study was to investigate regulation of neurogenic airway inflammation via the dorsal vagal complex (DVC).
METHODS: Neuronal activity in the DVC and transmitter expression as well as its effects on regulation of airway inflammation were observed in a guinea pig model of GER. The effects of DVC on SP expression and microvascular leakage of airway were measured using a stereotaxic technique combined with microinjection to change the activities of neurons or SP concentration in the target area. The pseudorabies virus Bartha (PRV Bartha) was used as a retrograde tracer to examine the pathway from DVC to airway.