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Allergy and Airway: Asthma III |

Regulation of Neurogenic Airway Inflammation via the Dorsal Vagal Complex in a Guinea Pig Model of Gastroesophageal Reflux

Zhe Chen; Le-jia Sun; Hui Chen; Da-chuan Gu; Wei-tao Zhang; Rong Dong; KeFang Lai
Author and Funding Information

State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical College, Guangzhou Institute of Respiratory Diseases, Guangzhou, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A26. doi:10.1016/j.chest.2016.02.028
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SESSION TITLE: Asthma III

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: The aim of the study was to investigate regulation of neurogenic airway inflammation via the dorsal vagal complex (DVC).

METHODS: Neuronal activity in the DVC and transmitter expression as well as its effects on regulation of airway inflammation were observed in a guinea pig model of GER. The effects of DVC on SP expression and microvascular leakage of airway were measured using a stereotaxic technique combined with microinjection to change the activities of neurons or SP concentration in the target area. The pseudorabies virus Bartha (PRV Bartha) was used as a retrograde tracer to examine the pathway from DVC to airway.

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