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Allergy and Airway: Asthma III |

The Role of IL-17A in the Pathogenesis of Early Infection With RSV Increasing Susceptibility to Asthma

Zhijun Jie; Xiao Sun; Yanchao He, MD; Wei Sun; Jindong Shi
Author and Funding Information

The Fifth hospital of Shanghai, Shanghai, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A24. doi:10.1016/j.chest.2016.02.026
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SESSION TITLE: Asthma III

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE:The role of IL-17A in the pathogenesis of early infection with RSV increasing susceptibility to asthma.

METHODS: Establishing a mice model of immune tolerance by oral feeding with OVA, and infected with RSV before arousing airway high reactivity. Neutralizing IL-17A before infected with RSV. After the last challenge with OVA the mice were analyzed for AHR, eosinophil infiltration, levels of cytokines, IgE production, percentage of Th2 and Th17 cell, and lung histology.

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