Allergy and Airway: Asthma II |

Altered Serum IgE and IgG4 Response to Dermatophagoides Pteronyssinus Allergens During Specific Immunotherapy FREE TO VIEW

Baoqing Sun
Author and Funding Information

Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A23. doi:10.1016/j.chest.2016.02.025
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SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: We investigated the changes in serum-specific IgE (sIgE) and IgG4 (sIgG4) against house dust mite (HDM) and its components Der p 1 and Der p 2 during specific immunotherapy (SIT), and evaluated the clinical efficacy thereof.

METHODS: We retrospectively analyzed 51 HDM-sensitized children aged 5 to 16 years diagnosed with allergic rhinitis and/or asthma, following 36 months of SIT. We also collected data from a contemporary control cohort of 50 patients administered routine medications for HDM allergy. In the test cases, we recorded the sIgE and sIgG4 levels against the whole allergen of HDM (Der p), Der p 1 and Der p 2 at baseline and at 6, 12, 24 and 36 months of SIT.

RESULTS: The serum sIgE response increased up to 6 months of SIT, but subsequently declined. At 36 months, the anti-Der p 1 and anti-Der p 2 sIgEs plummeted below the baseline. During SIT, the increased serum sIgG4 response was the greatest against Der p, followed by Der p 1 and Der p 2. The decline in sIgE/sIgG4 ratio for Der 1 was higher than for the other allergensmaximum decline. Compared with older children, children aged 5 to 8 manifested a clearer sIgG4 response, especially against Der p 1 and Der p 2 versus Der p.

CONCLUSIONS: SIT for HDM stimulated an early sIgE and sIgG4 response against HDM allergens. with a progressive decline in the ratio of sIgE/sIgG4, especially against Der p 1.

CLINICAL IMPLICATIONS: Younger children may manifest a more rapid response to SIT than older ones.

DISCLOSURE: The following authors have nothing to disclose: Baoqing Sun

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