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Allergy and Airway: Asthma II |

Plasmacytoid Dendritic Cell in Peripheral Blood Are Significantly Elevated in Asthma FREE TO VIEW

Liu Xiaofan, MMed
Author and Funding Information

The Central Hospital of Wuhan, Wuhan, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A22. doi:10.1016/j.chest.2016.02.024
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Published online

SESSION TITLE: Asthma II

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: To investigate the difference about the absolute number and percentage in peripheral blood DC subjects (myeloid DCs, mDC and plasmacytoid DCs, pDC) between Classic Asthma (CA) and Cough variant asthma, at the same time to study the effect of cigarette smoke on asthma. To investigate the difference about the absolute number and percentage in peripheral blood DC subjects (myeloid DCs, mDC and plasmacytoid DCs, pDC) between Classic Asthma (CA) and Cough variant asthma, at the same time to study the effect of cigarette smoke on asthma.

METHODS: 20 patients with classic asthma, 17 patients with cough variant asthma and 17 healthy subjects as control were enrolled in this study. Peripheral blood DC subsets were analyzed by flow cytomety with the Miltenyi blood DC enumeration kit.

RESULTS: The CA and CVA group showed significantly increased pDC count and decreased ratio of mDCs to pDCs compared with controls, but there were no diffence between CA and CVA.

CONCLUSIONS: The immunological pathogenesis of CVA is similar to CA. These data indicate that the patients with CA or CVA had a polarization of the mDC:pDC balance toward pDCs, which increase the imbalance of Th1/Th2.

CLINICAL IMPLICATIONS: Given that pDCs are in favor of tolerogenic the function, our data support that pDCsimmunosuppressive properties in the CVA.

DISCLOSURE: The following authors have nothing to disclose: Liu Xiaofan

No Product/Research Disclosure Information


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