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Allergy and Airway: Asthma II |

Chemical Chaperones Reverses Autophagic Dysfunction Resulting From Bronchial Asthma in the Lung Tissues of OVA-OVA Mice via Modulating NF-κB Activation

Bo Zhou
Author and Funding Information

The First Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A17. doi:10.1016/j.chest.2016.02.019
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SESSION TITLE: Asthma II

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: Chemical chaperones has been considered as an important regulator of bronchial asthma by improving airway inflammation, however the mechanism of chemical chaperones involved in insulin resistance remains not fully understood. In the present study, we investigated the effect of chemical chaperones (4-phenylbutyric acid, 4-PBA) on autophagy secondary to bronchial asthma in the lung tissues of OVA-OVA mice and in bronchial epithelial cell models, and clarified the intracellular events responsible for chemical chaperones-mediated effects.

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