Allergy and Airway: Asthma I |

Preliminary Study on Bronchial Thermoplasty in the Treatment of Severe Asthma FREE TO VIEW

Qingling Zhang; Rihuang Qiu; Xiaoxian Zhang; Yu Chen; Mo Xian; Jing Li; Shiyue Li
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State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Diseases, The First Affiliated Hospital, Guangzhou, China

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A15. doi:10.1016/j.chest.2016.02.017
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SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: We sought to assess the effectiveness and safety of BT in asthmatic patients 1 year after therapy.

METHODS: The safety and effectiveness of BT was studied in 6 subjects with severe asthma. Baseline and post-treatment measurements included spirometry, daily diary recordings of peak flow, symptoms, and medication usage. Subjects completed follow-up evaluations at 6 mon and 12mon.

RESULTS: The most common adverse events are cough, wheezing, lower respiratory infection and atelectasis (24.1%, 13.8%, 10.3%, 10.3%, repectively). Data from 6-mon daily recordingsdiaries collected for 6 mon indicated significant improvements under baseline in frequency of acute exacerbations (p=0.027), variation of PEF (p=0.008), dose of ICS (p=0.02) and, dose of OCS (p=0.037). Compared to baseline, miniAQLQ scores (6.4±0.5vs.5.2±0.9, p=0.031) and symptom-free days (21.2±7.2vs.14.5±3.7, p=0.05) were significantly improved at 6 mon. All abovethe measurements above were improved at 12 mon. ACQ-6 scores, ACT scores, PEF values and spirometry measurements remained stable throughout the study period.

CONCLUSIONS: The results appeared to be an improvement in the control of asthma without obvious side effects after being treated with thermoplasty. Therefore, bronchial thermoplasty might offer a new approach to treatfor severe asthma

CLINICAL IMPLICATIONS: We sought to assess the effectiveness and safety of BT in asthmatic patients, The results of this study indicated bronchial thermoplasty might offer a new approach to treat severe asthma.

DISCLOSURE: The following authors have nothing to disclose: Qingling Zhang, Rihuang Qiu, Xiaoxian Zhang, Yu Chen, Mo Xian, Jing Li, Shiyue Li

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