RESULTS: In the FA group, most of the cases are eosinophilic asthma (48.8%) while in the NFA group, the major phenotype are neutrophilic, eosinophilic and mixed granulocytic asthma (25.9%, 29.6% and 29.6% respectively). There is no evident difference in FeNO between two groups (34±25.5 vs. 46.4±30.3, P=0.116). The FVC pred% of the FA group is lower compared to the NFA group (81.5±24.7 vs. 89.69±14.53, P<0.05). The FEV1pred% and FEV1/FVC in FA group are not significantly lower than that in NFA group (59.7±24.9 vs. 68.53±23.32, P=0.65; 57.1±15.2 vs. 58.46±18.05, P=0.656). The patients with fungus allergic tend to need more daily ICS than those in the NFA group (516±238 vs. 320±250, P<0.01). The level of total IgE in the FA group is higher than the other group (1632±1423 vs.249±125, P<0.01). Almost all 41patients with fungus-allergic are aspergillus-related-specific-IgE positive, while 46.3% are Cladosporium-related-specific-IgE positive and 48.8% are alternaria-related-specific-IgE positive.