Extrapulmonary sarcoidosis is close on the differential diagnosis to GLUS syndrome. Similarly, it can present with lymphadenopathy, splenomegaly, hepatomegaly, and abnormal blood counts. However, unlike GLUS syndrome, elevated serum calcium, 1,25-dihydroxyvitamin D, and angiotensin-converting enzyme are common findings in sarcoidosis although they are not specific or sensitive enough to clarify the diagnosis. In contrast to GLUS syndrome, thoracic imaging of sarcoidosis shows not just lymphadenopathy but also progressive parenchymal disease as sarcoidosis advances. Sarcoidosis is typically associated with histologic findings of noncaseating granulomas that are deficient in B cells and are associated with T-cell lymphocytes. Glucocorticoids, the standard of therapy for sarcoidosis, are often used to treat exacerbation with the duration sometimes prolonged; its actions on the disease can be variable in onset and degree in different patients.