The diagnostic yield of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in sarcoidosis has been shown to vary from 54% to 93% with a pooled diagnostic accuracy of 79%., It remains unclear whether the use of a larger bore aspiration needle during EBUS-TBNA increases the diagnostic yield in sarcoidosis.,,,, In a prospective, double-blind, randomized controlled trial, subjects with clinicoradiologic suspicion of sarcoidosis were assigned (1:1) to undergo EBUS-TBNA with either a 21- or 22-gauge needle. Endobronchial biopsy and transbronchial lung biopsy (TBLB) were performed at the discretion of the bronchoscopist. The primary outcome was the diagnostic yield (detection of granulomas) of EBUS-TBNA in subjects finally receiving a diagnosis of sarcoidosis. The secondary outcomes were adequacy of samples, granuloma density, and adverse events during the procedure. The study protocol (e-Table 1) was approved by the ethics review committee (1Trg/PG-2014/12543-54), and written informed consent was obtained from all subjects. The trial was registered at www.clinicaltrials.gov (NCT02459431).