Leo Fabbri is a true giant in respiratory research, particularly in the fields of asthma and COPD, in which he has made important contributions to their understanding and management. He is Professor of Respiratory Medicine, Honorary Professor of Internal Medicine, and Director of the Department of Department of Oncology, Hematology and Respiratory Diseases at the University of Modena and Reggio Emilia, Modena, Italy. He received his Doctorate in Medicine and Surgery, University Padua, in 1972; Board in Occupational Medicine, University Padua, in 1975; and Board of Respiratory Medicine, University Bologna, in 1978. In 1980, he spent a year at Tulane University with Hans Weill and John Salvaggio. He then moved to the Cardiovascular Research Institute at the University of California in San Francisco with Jay Nadel for 2 years, which is where we first met.