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Editorial |

Use of Parenteral Prostanoids: Important Insights for CHEST Physicians

C. Gregory Elliott, MD, FCCP
Author and Funding Information

CORRESPONDENCE TO: C. Gregory Elliott, MD, FCCP, Department of Medicine, Intermountain Medical Center, 5121 S. Cottonwood, #307, Murray, UT 84107


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(3):615-616. doi:10.1016/j.chest.2015.11.024
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In 1951, Dresdale et al described “primary pulmonary hypertension” (PPH), a progressively fatal disease for which there was no effective treatment. Then, in 1984, Higenbottam et al reported that a continuous infusion of epoprostenol dramatically improved the health of a young woman who was bedridden with PPH. Twelve years later, Barst et al showed that continuous infusion of epoprostenol produced symptomatic and hemodynamic improvement as well as improved survival for patients with severe PPH. Soon, others demonstrated the benefits of epoprostenol infusion in patients with “secondary” pulmonary hypertension; this led to a paradigm shift that allowed physicians to administer epoprostenol to patients with severe pulmonary arterial hypertension (PAH).

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