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Editorials: Point and Counterpoint |

POINT: Does Low-Dose Oxygen Expose Patients With COPD to More Radiation-Like Risks Than Patients Without COPD? Yes

Vincent J. Kopp, MD; Joseph M. Stavas, MD
Author and Funding Information

FINANCIAL/NONFINANCIAL DISCLOSURES: The authors have reported to CHEST the following: J. M. S. consults for Cook, Inc. (West Lafayette, IN) and Excelerate Health Ventures, Inc. (Durham, NC). None declared (V. J. K.).

CORRESPONDENCE TO: Vincent J. Kopp, MD, Department of Anesthesiology, Campus Box 7010, N2198 UNC Hospitals, Chapel Hill, NC 27599-7010


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(2):303-306. doi:10.1016/j.chest.2015.10.073
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Extract

We argue that low-dose oxygen therapy (LDOT) does expose patients with COPD to more radiation-like risks than patients without COPD. Three considerations subtend our assertion: radiation and oxygen share oxidative stress mechanisms that constitute radiation-oxygen injury homology (ROIH); patients with COPD have higher, more problematic exposure rates to LDOT vs patients without COPD; and patients with COPD vs patients without COPD have disease burdens that amplify ROIH from LDOT. Thus, LDOT, independent of benefits, poses radiation-like risks with pernicious results that follow stochastic patterns.,

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