Patients with COPD have high comorbidity burdens. Most have radiation-oxygen injury homology foundations. Untimely emergence/exacerbation/exaggeration of comorbidities expose patients with COPD to health risks independent of COPD risks. Such risk is heightened when surgical intervention is required to address conditions such as heart attack or stroke, glaucoma, cataracts, or gastrointestinal conditions. Although we cannot prove that LDOT worsens comorbidities, excessive oxygen causes or contributes to cerebral and systemic arterial vasoconstriction, microvascular proliferation, diminished cardiac output, cataracts, and even central corneal thickening.