The article “Community-acquired pneumonia: pathogenesis of acute cardiac events and potential adjunctive therapies” by Feldman and Anderson was an excellent and clinically relevant review of the pathogenesis and therapeutic implications of acute cardiac events in pneumonia. An important addition to the otherwise comprehensive work might have been discussion of the role of cardiac biomarkers in the prediction of mortality in patients with community-acquired pneumonia (CAP). Several natriuretic peptides, neurohormones that are released in response to cardiac stress, have been associated with higher risk of poor outcomes in CAP. These include B-type natriuretic peptide,, N-terminal pro B-type natriuretic peptide, and midregional pro-atrial natriuretic peptide. A recent study found that the natriuretic peptides provided increased discrimination when added to the Pneumonia Severity Index compared with the Pneumonia Severity Index alone, and were especially useful in identifying patients at high risk for mortality. The predictive value of these cardiac biomarkers further illustrate the important interplay between cardiac stress and mortality in CAP.