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Recent Advances in Chest Medicine |

Persistent Challenges in Pediatric Pulmonary Hypertension

Rachel K. Hopper, MD; Steven H. Abman, MD; D. Dunbar Ivy, MD
Author and Funding Information

FUNDING/SUPPORT: This study was supported by the Jayden DeLuca Foundation; the Leah Bult Foundation; the Frederick and Margaret L Weyerhaeuser Foundation; and National Institutes of Health (NIH)/National Center for Advancing Translations Sciences Colorado CTSA [Grants UL1 TR001082 and NIH U01 HL081335].

aDepartment of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Children’s Hospital of Philadelphia, Philadelphia, PA

bDepartment of Pediatrics, University of Colorado School of Medicine, Children’s Hospital Colorado, Aurora, CO

CORRESPONDENCE TO: Rachel K. Hopper, MD, The Children's Hospital of Philadelphia, 3401 Civic Center Blvd, Room 8NW90, Philadelphia, PA 19104


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;150(1):226-236. doi:10.1016/j.chest.2016.01.007
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Pulmonary hypertension and related pulmonary vascular diseases cause significant morbidities and high mortality and present many unique challenges toward improving outcomes in neonates, infants, and children. Differences between pediatric and adult disease are reflected in controversies regarding etiologies, classification, epidemiology, diagnostic evaluations, and therapeutic interventions. This brief review highlights several key topics reflecting recent advances in the field and identifies persistent gaps in our understanding of clinical pediatric pulmonary hypertension.

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