Dr Turner also asks whether we assessed the relationship between physiologic measures of intensity of spontaneous cough and cough-related quality of life. We did not find a relationship between baseline Leicester Cough Questionnaire score and physiologic measures of spontaneous cough intensity. In our opinion, the lack of association is not surprising because the Leicester Cough Questionnaire is a measure of cough-specific quality of life during a 2-week period, whereas our physiologic assessment of spontaneous cough was performed during a single recording in a laboratory setting. Furthermore, quality of life is influenced by numerous other factors such as frequency of cough and its adverse effects. We did not assess subjective ratings of cough intensity in the patient’s own environment to enable a comparison with quality of life. As Dr Turner points out, our sample size of subjects who underwent study of spontaneous cough was underpowered for comparisons with quality-of-life measures, which also may be relevant. A more suitable comparison may be possible once ambulatory measures of cough intensity are developed. Combining longitudinal assessments of cough intensity with already available measures of cough frequency may allow a comprehensive objective assessment of cough and help establish their relationship with patients' perception of cough severity and effect on quality of life.