0
Editorials |

AutoimmunityAutoimmunity Pathway to UIP: A Pathway to Usual Interstitial Pneumonia?

Marvin Schwarz, MD, FCCP
Author and Funding Information

From the Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado School of Medicine.

CORRESPONDENCE TO: Marvin Schwarz, MD, FCCP, Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado School of Medicine, 12700 E 19th Ave, Aurora, CO 80045; e-mail: marvin.schwarz@ucdenver.edu


CONFLICT OF INTEREST: M. S. is a member of the advisory board of Boehringer-Ingelheim GmbH and Genentec/Roche; the Data and Safety Monitoring Board of Bristol-Myers Squibb Company and FibroGen, Inc; and the clinical endpoint committee of Merck & Co, Inc.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.


Chest. 2015;148(6):1367-1369. doi:10.1378/chest.15-1323
Text Size: A A A
Published online

Extract

Of the histologic patterns that define the interstitial pneumonias, regardless if idiopathic, familial, or from a known cause, usual interstitial pneumonia (UIP) remains the most ominous. The known causes include connective tissue diseases (CTDs), asbestos, and organic antigen exposure causing chronic hypersensitivity pneumonitis. All can result in a UIP lesion but have other histologic features that point to the etiology. In the case of CTD, in addition to the UIP histology, there are various combinations of interstitial lymphoplasmacytic infiltrates, parenchymal lymphoid follicles with germinal centers, pleuritis, and increases in the amount of perivascular collagen.1 Moreover, CTD-interstitial lung disease (CTD-ILD) can also appear histologically and radiographically as acute interstitial pneumonia, organizing pneumonia, nonspecific interstitial pneumonia (NSIP), or as combinations of the histologic patterns.

First Page Preview

View Large
First page PDF preview

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543