0
Miscellaneous |

Needle in a Haystack: An Elusive Case of Tracheal Stenosis in Treated Granulomatosis With Polyangiitis

Abbas Shahmohammadi, MD; Wael Nasser, MD; Johan Barretto, MD
Author and Funding Information

University of Florida at Gainesville, FL, Gainesville, FL


Chest. 2015;148(4_MeetingAbstracts):643A. doi:10.1378/chest.2281887
Text Size: A A A
Published online

Abstract

SESSION TITLE: Miscellaneous Cases

SESSION TYPE: Affiliate Case Report Slide

PRESENTED ON: Wednesday, October 28, 2015 at 11:00 AM - 12:15 PM

INTRODUCTION: Granulomatosis with polyangiitis (GPA) can present with variety of symptoms. Respiratory tract involvement is common and can have variety of presentations including involvement of tracheobronchial tree. GPA involvement of tracheobronchial tree most commonly presents with tracheal stenosis. We present a case of a 22 years old female with treated GPA who presented with 10 day history of shortness of breath and wheezing. After extensive evaluation including inpatient pulmonary function testing(PFT) she was found to have tracheal stenosis.

CASE PRESENTATION: A 22 yo female with GPA presented with 10 day history of worsening shortness of breath (SOB) and wheezing. Her treatment included a recent course of Rituximab and prednisone taper which she was taking at presentation. Physical examination was remarkable for few upper lung zone wheezes, but no stridor. CBC was remarkable for mild anemia with hemoglobin of 12.0 g/dl and leukopenia with white blood cell count of 3.8 thou/cu mm. Chest xray and CT were normal without any evidence of parenchymal or tracheobronchial abnormality. Laryngoscopy done was normal without any supraglottic mucosal abnormality. Given the disproportionate complaints of SOB to exam and normal imaging findings, pulmonary function testing (PFT) was done. PFT was consistent with fixed upper airway obstruction with flattening of the inspiratory and expiratory limb of flow volume loop. Based on this finding, a bronchoscopy was done which revealed inflamed mucosa with subglottic tracheal stenosis with 50% narrowing of the airway. A balloon dilation was done. Patient had resolution of SOB and wheezing post bronchoscopy and follow up PFT revealed normal values with normalization of the flow volume loop.

DISCUSSION: Granulomatosis with polyangiitis can have variety of respiratory presentations including involvement of the tracheobronchial tree which most commonly presents with tracheal stenosis. This case demonstrates a diagnosis of tracheal stenosis made with inpatient PFT testing after extensive work up revealed no cause for the patient’s presentation of SOB and wheezing.

CONCLUSIONS: In patients with GPA presenting with SOB when routine test and imaging dose not reveal a cause for the presentation, before a more invasive testing or alternate work up is pursued, physicians should consider PFT testing.

Reference #1: King, TE. Respiratory tract involvement in granulomatosis with polyangiitis (Wegener's) In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. (Accessed on March 31, 2015)

DISCLOSURE: The following authors have nothing to disclose: Abbas Shahmohammadi, Wael Nasser, Johan Barretto

No Product/Research Disclosure Information


Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543