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Sleep Disorders |

Serum Vitamin D Levels and Obstructive Sleep Apnea: Is There an Association?

Avinash Ramdass, MD; Ena Gupta, MD; Monica Plazarte, MD; William Palfrey, MD; Harshit Shah, MD; Mae Sheikh-Ali, MD; Mariam Louis, MD
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University of Florida, Jacksonville, FL


Chest. 2015;148(4_MeetingAbstracts):1055A. doi:10.1378/chest.2281779
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Abstract

SESSION TITLE: Sleep Disorders Posters II: Consequences of OSA and Treatment

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 28, 2015 at 01:30 PM - 02:30 PM

PURPOSE: Obstructive Sleep Apnea (OSA) and Vitamin D deficiency (VDD) are both prevalent diseases in the US. Only three studies conducted in Europe have looked at the relationship between OSA and VDD, and they suggest a positive association. Proposed mechanisms include the interactions of inflammatory markers and myopathy and tonsillar hypertrophy from VDD. Given the paucity of data, we performed a retrospective study looking at the association between VDD and OSA in the USA.

METHODS: We performed a retrospective chart review of patients who had undergone polysomnography and who were also tested for Vitamin D. Baseline demographic characteristics, Apnea Hypopnea Index (AHI), Epworth Sleepiness Score (ESS), BMI and 25-hydroxy vitamin D levels (measured as ng/mL) were collected. Characteristics are reported as numbers (percentages) and as means (standard deviation) for categorical and continuous variables respectively.

RESULTS: We studied a total of 100 patients with mean age of 58 years and 71.7 % males. We divided the dataset into 4 categories - no OSA (AHI <5), mild (AHI 5-15/hr), moderate (AHI 15-30/hr) and severe (AHI > 30/hr). There were 9, 34, 29 and 27 patients respectively. Amongst all OSA patients, 75% had VDD (Vitamin D level 19.9±9.9). Vitamin D levels amongst mild, moderate and severe OSA were 22.7±10.0, 16.9 ±7.7, and 19.7±11.1 respectively, and levels were not statistically significant. There was a non-significant trend towards increasing percentage of Vitamin D deficient patients and OSA severity - no OSA (66.6%), mild (70.6%), moderate (82.8%) and severe (77.8%) OSA. There was no statistically significant difference in BMI, ESS and apneic events amongst Vitamin D deficient patients.

CONCLUSIONS: These data suggest there is no association between VDD and OSA, but that there was a non-significant trend towards increasing number of Vitamin D deficient patients with increasing severity OSA. These findings are in contrast to published data.

CLINICAL IMPLICATIONS: Prospective studies are needed to determine if there is indeed an association between VDD and OSA and potentially help guide treatment for these diseases.

DISCLOSURE: The following authors have nothing to disclose: Avinash Ramdass, Ena Gupta, Monica Plazarte, William Palfrey, Harshit Shah, Mae Sheikh-Ali, Mariam Louis

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