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Diffuse Lung Disease |

Changes in Myocardial Performance in Sarcoidosis Patients

Aysel Kederli, MD; Sumeyye Gullulu, MD; Funda Coskun, MD; Dilber Yilmaz, MD; Esra Uzaslan, MD
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Uludag University Medical Faculty Cardiology Department, Bursa, Turkey


Chest. 2015;148(4_MeetingAbstracts):396A. doi:10.1378/chest.2281101
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Abstract

SESSION TITLE: Diffuse Lung Disease Posters

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 28, 2015 at 01:30 PM - 02:30 PM

PURPOSE: Despite myocardial sarcoid involvement has been reported in 20-27% in autopsy series, only 5% of the patients are clinically symptomatic. This study was planned to evaluate right and left ventricular functions in patients with early stage sarcoidosis (stage I and II) without any findings of cardiac involvement with Tei index which globally shows systolic and diastolic functions of the ventricles was used.

METHODS: Seventy-two patients under follow-up for sarcoidosis without cardiac involvement (53 women, 19 men; mean age 49.1 ± 10.3 years) and nineteen age-matched healthy control subjects (14 women, 5 men; mean age 48.7 ± 6.5 years) were enrolled in the study. All subjects were evaluated with two-dimensional and Doppler echocardiography. Right and left ventricle Tei indices (myocardial performance index) were calculated from measured Doppler parameters.

RESULTS: Peak velocity of the mitral A wave (A) was higher, peak velocity of the mitral E wave, E/A ratio were lower; and ejection time was shorter in patients with sarcoidosis (p< 0.05) compare to controls. Peak velocity of the tricuspid A wave was higher, E wave deceleration time was longer and E/A ratio was lower (p< 0.05) in sarcoidosis group. While left ventricular Tei index was higher in patients with sarcoidosis (p= 0.021), right ventricular Tei index was similar to healthy controls (p>0.05).

CONCLUSIONS: Left ventricular myocardial performance is disturbed in patients with early stage sarcoidosis.

CLINICAL IMPLICATIONS: Disturbances in left ventricular myocardial performance can be related to a subclinical involvement of sarcoidosis in early stages of sarcoidosis.

DISCLOSURE: The following authors have nothing to disclose: Aysel Kederli, Sumeyye Gullulu, Funda Coskun, Dilber Yilmaz, Esra Uzaslan

No Product/Research Disclosure Information


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