Pulmonary Physiology |

Proof of Concept Development of a Mobile Spirometer and Breath Sensor FREE TO VIEW

Laren Tan, MD; Alexander Fung, PhD; Theresa Duong, MD; Michael Schivo, MD; JP Delplanque, PhD; Cristina Davis; Nicholas Kenyon, MD
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UC Davis School of Medicine, Davis CA, Sacramento, CA

Chest. 2015;148(4_MeetingAbstracts):892A. doi:10.1378/chest.2280459
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SESSION TITLE: Pulmonary Physiology Posters

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 28, 2015 at 01:30 PM - 02:30 PM

PURPOSE: We have developed a prototype of a novel, inexpensive pressure-differential spirometer that can be used with a portable tablet or phone. Our purpose here was to 1) validate the spirometer and 2) determine whether breath volatile gas sensors could be added to the device. We compared lung function measures and measured exhaled CO in normal subjects, asthmatics and COPD patients.

METHODS: After signing informed consent, 16 non-asthmatics, 9 asthmatics and 8 COPD patients were asked to perform three acceptable spirometry maneuvers using a currently approved clinical spirometer. Subjects were then asked to repeat the same maneuvers three more times using the novel Android-based platform spirometer. Fractional exhaled carbon monoxide (FeCO) levels were measured during novel spirometer maneuvers.

RESULTS: Ninety seven spirometry readings were obtained among all subjects. The correlations between FEV1 readings between the mobile spirometer and clinic-based spirometer was very high (R=0.95, p<0.01). Correlation coefficients were similar for FEV6 values, but less for PEF rates. Exhaled breath gas measurements were feasible with an electrochemical sensor inserted into the system. Ninety-seven total readings for exhaled CO were in physiological ranges (mean FeCO 3.53 +/- 0.2 ppm) and were reproducible and reliable (R = 0.7, p<0.01).

CONCLUSIONS: Proof-of-concept validation studies with novel mobile spirometer in three groups of patients, two with obstructive lung diseases, showed that the spirometer was accurate and reliable. PEF readings proved more challenging and this could be due to coaching or delayed measuring response with the novel spirometer. FeCO with the mobile spirometer was feasible and reliable.

CLINICAL IMPLICATIONS: An inexpensive mobile phone based spirometer could improve accessibility to lung function testing in developing countries. It could also improve management of patients with obstructive lung disease in the community as lung function data could be transmitted to their physicians. Furthermore, exhaled breath analysis is feasible to introduce in future prototypes.

DISCLOSURE: The following authors have nothing to disclose: Laren Tan, Alexander Fung, Theresa Duong, Michael Schivo, JP Delplanque, Cristina Davis, Nicholas Kenyon

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