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Obstructive Lung Diseases |

Usefulness of the COPD Assessment Test (CAT) in Patients With (A) Stable Disease, and (B) Exacerbations

Chandramani Panjabi, MD; Shrikant Khake, MD; V.S. Isser, MD; G.S. Kochhar, MD
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Mata Chanan Devi Hospital, New Delhi, India


Chest. 2015;148(4_MeetingAbstracts):693A. doi:10.1378/chest.2280017
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Abstract

SESSION TITLE: COPD Posters II

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 28, 2015 at 01:30 PM - 02:30 PM

PURPOSE: (i) To prove the usefulness of the Chronic Obstructive Pulmonary Disease (COPD) Assessment Test (CAT) in out-patients with stable disease, and (ii) to assess whether the CAT is sensitive to changes in COPD health status during exacerbation states and thereafter in stable condition.

METHODS: 43 COPD patients (21 out-patients with stable disease and 22 in-patients with exacerbations), diagnosed as per the GOLD guidelines on the basis of clinical presentation and spirometry, were recruited. The St. George’s Respiratory Questionnaire (SGRQ) and the CAT questionnaire were administered to stable patients during routine out-patient visits. In patients with COPD exacerbation, both these questionnaires were completed firstly during the initial 24 hours of admission, and secondly when these patients returned for follow-up within 2-4 weeks after discharge from hospital. Spirometry was performed each time when the questionnaires were administered. The results of both the questionnaires were analysed, compared and correlated with spirometry findings.

RESULTS: In patients with stable disease, there was a statistically significant correlation between CAT score and both post bronchodilator FEV1 (r=-0.912, P<0.001) as well as FVC (r=-0.511, P=0.018). Significant positive correlations between CAT scores and SGRQ symptom score (r=0.958, P<0.001), SGRQ activity score (r=0.885, P<0.001), SGRQ impact score (r=0.892, P<0.001) and SGRQ Total score (r=0.917, P<0.001) were also found. In patients with COPD exacerbations too, there was a significant correlation between CAT score and FEV1 (r=-0.865, P<0.001) as well as FVC (r=-0.685, P=0.001). Significant positive correlations between CAT scores and SGRQ symptom score (r=0.890, P<0.001), SGRQ activity score (r=0.871, P<0.001), SGRQ impact score (r=0.919, P<0.001) and SGRQ Total score (r=0.929, P<0.001) during the initial period of hospitalisation were noted. At follow-up visit also, similar statistically significant findings were observed in the exacerbation group.

CONCLUSIONS: There is a strong correlation among CAT scores, SGRQ domain and total scores, and spirometry (FEV1 and FVC) parameters in COPD patients, both during the stable state and during exacerbations. The CAT questionnaire was found to be sensitive to changes in COPD health status during an acute exacerbation and thereafter in stable condition.

CLINICAL IMPLICATIONS: Since the CAT questionnaire is easier and takes less time to complete than the SGRQ, it is a useful tool to assess the impact of COPD on patients' health status.

DISCLOSURE: The following authors have nothing to disclose: Chandramani Panjabi, Shrikant Khake, V.S. Isser, G.S. Kochhar

No Product/Research Disclosure Information


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