Pulmonary Vascular Disease |

The Prevalence of Diabetes Mellitus in Pulmonary Arterial Hypertension and Its Relation to Severity and Survival FREE TO VIEW

Debapriya Datta, MD; Julianne Nichols, DO; Raymond Foley, DO; Diahann Wilcox, APRN-BC
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University of CT Health Ctr, Farmington, CT, Farmington, CT

Chest. 2015;148(4_MeetingAbstracts):942A. doi:10.1378/chest.2279068
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SESSION TITLE: Pulmonary Arterial Hypertension Posters I

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 28, 2015 at 01:30 PM - 02:30 PM

PURPOSE: Pulmonary Arterial Hypertension (PAH) occurs in patients with comorbid conditions which aren’t included in diseases “associated with” PAH. Limited knowledge exists regarding the association of Diabetes mellitus (DM) and PAH. Whether DM affects disease severity, progression and outcome in patients with PAH is not known.The objectives of this study were to determine: (i) The prevalence of DM in PAH. (ii) The correlation of DM with severity of PAH and mortality in PAH.

METHODS: The medical records of 74 patients with PAH, defined as mean pulmonary artery pressure (mPAP) >25mm Hg and mean pulmonary capillary wedge pressure (PCWP) < 15mmHg, being treated at the Pulmonary Hypertension (PH) Center at our institution, from 2007 to 2013 were reviewed. The following data was obtained: age, gender, Body Mass Index (BMI), presence of DM; mPAP at initial right heart catheterization. mPAP was used as a measure of severity of PAH. Survival (alive or expired) during period of follow-up at the PH Center was recorded. Survival and mPAP in diabetic and non-diabetic patients was compared using the independent t-test. Correlation of DM with mPAP and survival was determined by using Pearson’s test for linear correlation.

RESULTS: Of 74 patients, 75% were female; mean age was 64 + 14 years. DM was present in 10 patients (13.5%). Studied variables in diabetic and non-diabetic patients were as follows: BMI (kg/sqm) was 36 ± 7 in diabetics, 26± 6 in non-diabetis (p < 0.001). mPAP (mmHg) was 44 ± 12 in diabetics and 41 + 13 in non-diabetics (p=0.4). Sixty percent of diabetic patients and 36% of non-diabetis expired during follow-up. Using Pearson’s test for correlation, no significant correlation was noted between DM and mPA (r=0.093, p =0.45) as well as DM and survival (r= -0.099, p=0.4).

CONCLUSIONS: DM is present in 13.5% patients with PAH. Diabetic patients have a significantly higher BMI. Non-diabetic patients have a lower mortality during follow-up which was not statistically significant. DM has no impacton mPAP and survival respectively.

CLINICAL IMPLICATIONS: DM doesnot appear to have a significant impact on severity and mortality in PAH. Larger studies are needed to confirm these findings.

DISCLOSURE: The following authors have nothing to disclose: Debapriya Datta, Julianne Nichols, Raymond Foley, Diahann Wilcox

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