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Pulmonary Rehabilitation |

V'E/V'CO2 Slope in Asymptomatic Subjects Submitted to a Treadmill Ramp-Incremental Cardiopulmonary Exercise Testing: Associated Factors and One-Year Follow-up

Victor Dourado, PhD; Evandro Sperandio, PT; Agatha Matheus, PA; Vinicius Lauria, PA; Rodrigo Silva, PA; Antônio Gagliardi, MD; Marcello Romiti, MD; Rodolfo Arantes, MD
Author and Funding Information

Department of Health Sciences, Federal University of São Paulo, Santos, São Paulo, Brazil; Angiocorpore Institute of Cardiovascular Medicine, Santos, Brazil


Chest. 2015;148(4_MeetingAbstracts):910A. doi:10.1378/chest.2278823
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Abstract

SESSION TITLE: Pulmonary Rehabilitation Posters

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 28, 2015 at 01:30 PM - 02:30 PM

PURPOSE: The prognostic value of V’E/V’CO2 slope in patients has been well established. However, information related to the CPET performed on a treadmill is scarce. We aimed to assess V’E/V’CO2 slope and associated factors and its change over one year in asymptomatic adults submitted to a CPET on a treadmill.

METHODS: Five hundred and sixty-nine participants (44 ± 14 yr; 300 women) were enrolled. The initial evaluation included assessments of cardiovascular risk factors, lung function, body composition and 7 days of accelerometry. Then, the participants were submitted to a treadmill ramp-incremental CPET. The V’E/V’CO2 slope was calculated by means of a linear regression. Forty-three participants (47 ± 12 yr; 30 women) repeated the evaluations after one year of follow-up. Four hundred and foty-nine participants with less than 2 cardiovarcular risk factors and body mass index (BMI) < 30 kg/m2 were selected for providing reference equations.

RESULTS: At baseline, we observed week but significant correlations between V’E/V’CO2 slope and age (r = 0.13), FVC (r = -0.17), FEV1 (r = -0.19) and peak V'O2 (r = -0.26). We found no associations between V’E/V’CO2 slope and cardiovascular risk factors including directed measure of physical inactivity. After one-year follow-up, participants with higher BMI and lower FEV1 and FVC at baseline presented increased V’E/V’CO2 slopes, i.e., worse ventilatory efficiency (respectively r = 0.50, -0.36 and -0.41). Additionally, participants who presented increases in the amount of moderate-to-vigorous physical activity also presented shallower V’E/V’CO2 slope (r = 0.60). Reference equation included age, BMI and sex (R2 = 0.100). The mean values and 95% confidence interval for V’E/V’CO2 slope were 24 (19 - 33) and 26 (20 - 33) respectively for male and female subjects (p < 0.05)

CONCLUSIONS: We may conclude that V’E/V’CO2 slope is not associated with cardiovascular risk factors. Demographic atributes and anthropometrics were week but significant determinants for this imoirtant index. Our results suggest that physical activity in daily life, more then physical fitness, may play an important role in predicting increases in V’E/V’CO2 slope over time.

CLINICAL IMPLICATIONS: These data provide a frame of reference for assessing normal response of the V'E/V'CO2 slope. Strengths of our study include the assessment of V'E/V'CO2 slope on a treadmill and its change over time. Our results may be useful for better interpretation of the V'E/V'CO2 slope in patients with cardiopulmonary diseases.

DISCLOSURE: The following authors have nothing to disclose: Victor Dourado, Evandro Sperandio, Agatha Matheus, Vinicius Lauria, Rodrigo Silva, Antônio Gagliardi, Marcello Romiti, Rodolfo Arantes

No Product/Research Disclosure Information


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