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Chest Infections |

Diagnosing Latent Tuberculosis in Immunocompromised Patients Measuring Blood IP-10 Production Capacity: An Analysis of Chronic Renal Failure Patients

Ekrem Seyhan, MD
Author and Funding Information

Chest Disease, Medipol University, Medical Faculty, Chest Diseases, Istanbul, Küçükçekmece, Turkey


Chest. 2015;148(4_MeetingAbstracts):113A. doi:10.1378/chest.2278323
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Abstract

SESSION TITLE: Chest Infections Posters I

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 28, 2015 at 01:30 PM - 02:30 PM

PURPOSE: Patients undergoing haemodialysis for chronic renal failure (CRF-HD) are at risk of latent tuberculosis infection (LTBI). The effectiveness of using blood IP-10 production capacity to diagnose LTBI in CRF-HD patients was analysed.

METHODS: The study enrolled 50 CRF-HD patients. Interferon-gamma release assay (IGRA) was done using Quantiferon G-In-Tube (QFG-IT) system. Blood IP-10 production capacity was measured using the QFG-IT system tubes. Tuberculin skin testing (TST) was performed on the same day and the test results were compared.

RESULTS: TST turned out to be positive in 36.4% of the patients and QFG-IT in 54% of them. After stimulation with specific tuberculosis antigens, blood IP-10 levels increased noticeably. The antigen-stimulated blood IP-10 level was significantly higher in patients who were either TST or QFG-IT positive than in patients whose tests were negative (p=0.0001). Using 4.02 pg/mL as the threshold for stimulated blood log-transformed IP-10 level, good agreement was observed between IP-10 and QFG-IT results (κ=1).

CONCLUSIONS: Blood IP-10 level, which can be measured simply, provides results equivalent to interferon-γ release assays for the diagnosis of LTBI in CRF-HD patients.

CLINICAL IMPLICATIONS: Measurement of blood IP-10 levels after stimulation with specific TB antigens might be reliable for diagnosing LTBI in CRF-HD patients.

DISCLOSURE: The following authors have nothing to disclose: Ekrem Seyhan

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