Chest Infections |

The Value of the Tuberculin Skin Test and QuantiFERON-TB Gold In-Tube Test in the Development of Active Tuberculosis, in the Hemodialysis Patients and in Healthy Individuals FREE TO VIEW

Akif Özgül
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Yedikule Teaching Hospital for Chest Diseases and Thoracic Surgery, Istanbul, Turkey

Chest. 2015;148(4_MeetingAbstracts):133A. doi:10.1378/chest.2278274
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SESSION TITLE: Chest Infections Posters: Tuberculosis

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 28, 2015 at 01:30 PM - 02:30 PM

PURPOSE: Hemodialysis (HD) patients are at increased risk of reactivation of latent tuberculosis infection (LTBI) compared with the general population. QuantiFERON-TB Gold (QFT-G) for LTBI detection is more promising than tuberculin skin test (TST) in HD patients. However, their prognostic value for progression from LTBI to active tuberculosis (TB) has yet to be established.

METHODS: The study enrolled 100 HD patients and 90 age-matched, healthy controls. The TST and new interferon-γ blood tests, QuantiFERON-TB Gold (QFT-G) were performed. Five patients were lost during the follow-up period. 95 patients and all the healty conntrols were followed up 5 years for active TB disease.

RESULTS: Compared to the healthy controls, a high prevalence of LTBI was found in the ESRD patients by TST (34 %), QFT-G (43 %). Four (4%) HD patients progressed to TB disease within the 5-year follow-up. In HD patients, sensitivity, specificity, positive and negative predictive values of QFT-G and TST for active TB was 100 % and 25 %, 62% and 67%, 10% and 3 %, and 100% and 95%, respectively. Roc anaysis revealed that the results are significantly different (p=0.04).

CONCLUSIONS: QuantiFERON TB-2G test is a more useful diagnostic method than TCT for detecting those who will progress to active TB in HD patients.

CLINICAL IMPLICATIONS: QuantiFERON TB-2G was the more accurate method for identifying those truly infected with Mycobacterium tuberculosis, even in BCG-vaccinated individuals

DISCLOSURE: The following authors have nothing to disclose: akif özgül

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