Sleep Disorders |

PaO2 as a Predictive Factor for Sleep Respiratory Disorders in Patients With Chronic Obstructive Pulmonary Disease FREE TO VIEW

Jose Silva Junior, MS; Marcelo Rabahi, PhD; Marcus Conde, PhD; Krislainy Corrêa, PhD; Helena Rabahi, BS; Arthur Rocha, MD
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Federal University of Goias, Goiania, Brazil; Faculdade de Medicina de Petrópolis/FASE, Petropolis, Brazil; Clinica do Aparelho Respiratório (CLARE), Goiania, Brazil; Centro Médico, Goiania, Brazil

Chest. 2015;148(4_MeetingAbstracts):1043A. doi:10.1378/chest.2277980
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SESSION TITLE: Sleep Disorders Posters I: Diagnosis

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 28, 2015 at 01:30 PM - 02:30 PM

PURPOSE: To determine the prevalence of sleep respiratory disorders (isolated nocturnal hypoxemia and/or obstructive sleep apnea (OSA)) and predictive variables among subjects with Chronic Obstructive Pulmonary Disease (COPD).

METHODS: A cross-sectional study was performed in clinically stable COPD subjects visiting an Out Patient Chest Clinic in Goiania (Brazil). Patients were submitted to clinical evaluation, spirometry, polysomnography, echocardiography, arterial blood gas analysis, 6-minute walk testing and chest radiograph.

RESULTS: During the period of study 60.9% (39/64) COPD patients were diagnosed with sleep respiratory disorders (14 with OSA and 25 with isolated nocturnal hypoxemia). PaO2≤70mmHg (OR:4.59; 95% CI: 1.54-13.67; p=0.01) was significantly associated with sleep respiratory disorders.

CONCLUSIONS: The prevalence of sleep respiratory disorders was high (60.9%). The present study suggests that COPD patients with PaO2≤70mmHg are candidate to a sleep study.

CLINICAL IMPLICATIONS: There is limited available data and there is no agreement concerning how or when COPD patients should be evaluated for sleep respiratory disorders. Currently, in patients with COPD, polysomnography is mainly performed when OSA is suspected, due to symptoms like heavy snoring and excessive daytime sleepiness, or to fatigue, pulmonary hypertension or polycythemia, and it is not known which COPD patients without OSA symptoms should undergo a polysomnogram. The major finding of the present study is that resting PaO2 could be a parameter to identify patients to be submitted to a sleep study.

DISCLOSURE: The following authors have nothing to disclose: Jose Silva Junior, Marcus Conde, Krislainy Corrêa, Helena Rabahi, Arthur Rocha, Marcelo Rabahi

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