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Obstructive Lung Diseases |

Comorbidity as a Significant Contributor to Frequent Severe Acute Exacerbation Requiring Hospital Admission in COPD Patients

Suk Hyeon Jeong, MD; Hyun Lee, MD; Bok Soon Chang, MD; Hye Yun Park, MD; Man Pyo Chung, MD; Ho Joong Kim, MD; O Jung Kwon, MD; Gee Young Suh, MD
Author and Funding Information

Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea (the Republic of)


Chest. 2015;148(4_MeetingAbstracts):736A. doi:10.1378/chest.2277222
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Abstract

SESSION TITLE: COPD Posters VI

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 28, 2015 at 01:30 PM - 02:30 PM

PURPOSE: Chronic obstructive pulmonary disease (COPD) is a complex disease with extrapulmonary comorbidities, which often contribute to exacerbations. However, there are few studies to investigate impact of comorbidity on frequent severe exacerbations requiring hospitalization in COPD patients. Thus, we aimed to identify factors (including comorbidity) associated with recurrent hospital admissions in COPD patients with severe acute exacerbation (AE).

METHODS: A retrospective observational study was carried out in Samsung medical center (a 1,961-bed referral hospital in Seoul, Korea). We studied a total of 82 patients with severe AE between February 2012 and January 2014 and outcomes were evaluated for a year from the first admission day.

RESULTS: Of 82 patients, 31 patients (38%) developed recurrent severe AEs (median time to first exacerbation). In comorbidities, cardiovascular disease (P=0.041) were significantly higher in patients with recurrent severe AEs compared to those without recurrent severe AEs, while diabetes, asthma, lung cancer and tuberculosis destroyed lung were similar between two groups. In other clinical factors, lower forced expiratory volume in 1 second (P=0.006), home oxygen therapy (P=0.002) and long term oral steroid use (P=0.037) were significantly associated with recurrent severe AEs. In multivariate analysis, cardiovascular disease was an independent factor related to recurrent severe AE (OR: 3.10, P =0.046) There were no significant differences were found in hospital days, hospital and 1 year mortality between two groups.

CONCLUSIONS: Recurrent severe AEs of COPD was associated with comorbidity of cardiovascular disease as well as home oxygen therapy.

CLINICAL IMPLICATIONS: Comorbidity should be considered as a significant contributor to frequent severe AEs in COPD patients.

DISCLOSURE: The following authors have nothing to disclose: Suk Hyeon Jeong, Hyun Lee, Bok Soon Chang, Hye Yun Park, Man Pyo Chung, Ho Joong Kim, O Jung Kwon, Gee Young Suh

No Product/Research Disclosure Information


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