Diffuse Lung Disease |

Tp-E Interval in Sarcoidosis FREE TO VIEW

Seda Tural Onur; Imran Onur; Sinem Sokucu; Senay Aydin; Ekrem Karaayvaz; Samim Emet; Erdogan Cetinkaya
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Yedikule Chest Disease and Thoracic Surgery Training and Research Hospital, Chest Disease, Istanbul, Turkey

Chest. 2015;148(4_MeetingAbstracts):399A. doi:10.1378/chest.2276210
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SESSION TITLE: Diffuse Lung Disease Posters

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 28, 2015 at 01:30 PM - 02:30 PM

PURPOSE: The interval from the peak to the end of the electrocardiographic T wave (Tp-e) may correspond to the repolarization of the transmural tissue and in the literature increased Tp-e interval is associated with malignant ventricular arrhythmias. Only 5% of patients with sarcoidosis have signs or symptoms of cardiac involvement. Sarcoidosis amplifies inhomogeneity in ventricular repolarization, which significantly correlates with ventricular fibrillation. Changes in Tp-e in the progression of sarcoidosis have not been thoroughly investigated previously.

METHODS: All the patients diagnosed sarcoidosis with radiological and pathological criteria were included and questinaires were done to all patients. All the retrospective data of the patients about full blood count analyses, biochemical results, respiratory function tests, radiological findings, state of the disease, comorbid diseases and medicine they have used were recorded. After 12-lead ECG was taken from all patients, atrio-ventricular conduction abnormalities and ECGs without clearly analyzable QT segment were excluded. Also hypertension, chronic renal failure, coronary artery disease and malignancy patients were excluded from the study.

RESULTS: We enrolled 38 healthy control group and 72 sarcoidosis patients in our study. 30,55% were male in the sarcoidosis group and 34,21% were male in the control group. There was no significant difference between the groups for gender (P = 0.83). The mean age was 44,9 ± 1,04 years (21-72) in the sarcoidosis group and 48,86±1,14 years (27-67) in the control group. There was no significant difference between the groups for age (p=0.07). There was significantly increase for Tp-e results in the sarcoidosis group compared to the control group (77.02 ±11.76; 70.63± 12.510; respectively; P = 0.015).

CONCLUSIONS: In conclusion, we have presented a strong evidence suggesting that Tp-e interval were increased in sarcoidosis patients, which suggest that there might be a link between sarcoidosis and ventricular arrthymias and sudden death. Sarcoidosis patients with increased Tp-e interval should be in caution for sudden death and this will be life-saving.

CLINICAL IMPLICATIONS: Electrocardiography easily accessible and inexpensive tests for clinical use. In sarcoidosis patients it's important to early diagnose sudden death and ventricular arrhythmia' risk will be life-saving.

DISCLOSURE: The following authors have nothing to disclose: Seda Tural Onur, Imran Onur, Sinem Sokucu, Senay Aydin, Ekrem Karaayvaz, Samim Emet, Erdogan Cetinkaya

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