Pulmonary Physiology |

Impact of Body Mass Index on Cardiopulmonary Exercise Test Variables FREE TO VIEW

Antranik Mangardich, MD; Nancy McLellan, RRT; Debapriya Datta, MD
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University of Connecticut Health Center, Hartford, CT

Chest. 2015;148(4_MeetingAbstracts):895A. doi:10.1378/chest.2275004
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SESSION TITLE: Pulmonary Physiology Posters

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 28, 2015 at 01:30 PM - 02:30 PM

PURPOSE: Obesity can affect exercise capacity. The impact of Body Mass Index(BMI) on Cardiopulmonary Exercise Test (CPEXT) results is not well known. The objective of this study was to determine the effect of BMI on CPEXT variables.

METHODS: Records of patients who underwent CPEXT for evaluation of unexplained dyspnea in our institution over the last 5 years were reviewed. Parameters obtained included: age, gender, body mass index (BMI), anaerobic threshold (AT), Oxygen (O2) pulse, maximal O2uptake (VO2max), CO2 output (VCO2max), percent predicted heart rate (%Pred-HR) Heart rate reserve (HRR), Breathing reserve (BR), VO2/Work ratio, respiratory quotient (RQ), dead space (Vd/Vt), work performed in watts (Work-watts), percent predicted work (%Pred-Work), HR/VO2 and ventilatory equivalent for O2 (Ve/VO2) and CO2 (Ve/VCO2). The number of patients undergoing CPEXT, in whom an etiology of dyspnea could/could not be established, was noted. Pearson’s test for linear correlation was used to determine correlation between BMI and studied variables. p <0.05 was deemed statistically significant.

RESULTS: Of 163 patients, 65% were females; mean age was 53.5+ 16 years. Using Pearson’s test for linear correlation, a significant correlation was found between BMI and respectively %Pred-HR (r= -0.294, p<0.001), HRR (r=0.186, p=0.01), O2 pulse (r=0.249, p=0.001), VO2max in ml/kg/min (r=-0.373, p<0.001), RQ (r=0.26, p<0.001) and VO2/Work (r=0.302, p<0.001). No significant correlation was noted between BMI and respectively, AT, VO2 (L/min), Vd/Vt, BR, MVV, Ve/VO2, Ve/VCO2, Work-watts, %Pred-Work and HR/VO2. Diagnosis of cause of dyspnea was found in 68.7%; BMI did not impact diagnostic yield of CPExT (r= -0.085, p=0.2).

CONCLUSIONS: BMI has a significant impact on exercise capacity and a few cardiac parameters [O2-pulse (VO2/HR), %Pred-HR, HRR), but doesnot significantly affect ventilatory and gas exchange parameters. It doesnot influence diagnostic yield of CPEXT as patients’ work performance appears to be not significantly affected by BMI.

CLINICAL IMPLICATIONS: Awareness of the effect of BMI on cardiac parameters measured during exercise is important, to accurately interpret CPEXT results.

DISCLOSURE: The following authors have nothing to disclose: Antranik Mangardich, Nancy McLellan, Debapriya Datta

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