Obstructive Lung Diseases |

Impact of BMI on Cardiopulmonary Exercise Test Variables in Patients With COPD FREE TO VIEW

Ricardo Perez; Richard Zuwallack, MD; Debapriya Datta, MD
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UConn Health Center, Farmington, CT

Chest. 2015;148(4_MeetingAbstracts):695A. doi:10.1378/chest.2273628
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SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 28, 2015 at 01:30 PM - 02:30 PM

PURPOSE: COPD patients have reduced exercise capacity. The objective of this study was to determine the effect of elevated body-mass index (BMI) on exercise parameters during cardiopulmonary exercise testing.

METHODS: We reviewed the records of 60 COPD patients who underwent pulmonary rehabilitation at one of our hospitals. Exercise testing had been performed prior to starting pulmonary rehabilitation, per protocol. The following data were abstracted from records: age, gender, FEV1, six-minute walk distance (6MWD), peak oxygen uptake (VO2 peak), percent predicted VO2peak (VO2-PP), maximal minute ventilation (VEmax) and respiratory quotient (RQ). Pearson’s test for linear correlation was used to determine correlation between BMI and studied variables. These variables were compared in patients with BMI < 30 and BMI > 30, using independent t-test.

RESULTS: Fifty-seven percent were male; the mean age was 69 ± 8 years, BMI was 26 ± 5 kg/m2 (20% had BMI > 30), FEV1 was 51 ± 19%.; 6MWD was 309 ± 71 meters; VO2peak was 13 ± 4.5ml/kg/min; VO2-PP was 65 ± 21%; VEmax was 37 ± 14L/min; RQ at peak exercise was 0.95 ± 0.1. Using Pearson’s test for linear correlation, a significant correlation was noted between BMI and VEmax (r=0.471, p<0.001), indicating that increased weight was associated with greater minute ventilation requirement at peak exercise. No significant correlations were noted between BMI and the other parameters. On univariate analysis using t-test, no significant difference was noted in 6MWD, VO2pk, VO2-PP and RQ in patients with BMI >30 and < 30. However, VEmax was different between the 2 groups: VEmax 35 ± 12L/m and 46 ± 18 L/min for those with BMI below and above 30, respectively.

CONCLUSIONS: BMI is not related to peak exercise capacity, as measured by VO2 peak. It does, however, impact maximal minute ventilation during exercise: obese COPD patients have a higher VEmax than non-obese patients, but this does not affect exercise capacity.

CLINICAL IMPLICATIONS: More studies would be needed to further delineate the effect of BMI on exercise capacity in COPD.

DISCLOSURE: The following authors have nothing to disclose: Ricardo Perez, Richard Zuwallack, Debapriya Datta

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