Signs and Symptoms of Chest Diseases |

Underlying Causes of Fatal Hemoptysis: A Study of 69 Patients FREE TO VIEW

Xiaowen Hu, MD; Jay Ryu, MD
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Anhui Provincial Hospital, Hefei, China

Chest. 2015;148(4_MeetingAbstracts):1019A. doi:10.1378/chest.2272133
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SESSION TITLE: Signs and Symptoms of Chest Diseases Posters

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 28, 2015 at 01:30 PM - 02:30 PM

PURPOSE: Hemoptysis is a common presenting symptom in many pulmonary disorders and sometimes can lead to death. The underlying causes of fatal hemoptysis in the current era have not been examined.

METHODS: We retrospectively reviewed all patients with fatal hemoptysis at Mayo Clinic, Rochester, Minnesota between January 1, 2000, and December 31, 2013 through computer-assisted search and manual retrieved.

RESULTS: Sixty-nine patients were identified and included 28 (41%) patients in diffuse alveolar hemorrhage (DAH) syndrome. Only one-fourth of the subjects met the criteria for massive hemoptysis (greater than 200ml blood expectorated per a 24 hour period). Malignancy (n =37) and clotting disorder (n = 10; 90% iatrogenic) accounted for two-third of fatal hemoptysis cases. Lung cancer (56%) was the commonest type of malignancy but hematologic malignancy accounted for 43% of those with DAH. Bilateral lung infiltrates were the main findings in chest imaging and accounted for nearly three-fourth of all patients.

CONCLUSIONS: Malignancy and clotting disorder (mostly iatrogenic) were main causes of fatal hemoptysis. Lung cancer was the commonest type of malignancy but hematologic malignancy accounted for nearly one-half of those with DAH.

CLINICAL IMPLICATIONS: Characterize the underlying causes of fatal hemoptysis in this era in order to recognize them better to improve the prognosis.

DISCLOSURE: The following authors have nothing to disclose: Xiaowen Hu, Jay Ryu

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