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Prevalence of Restless Legs Syndrome in Adults With Sickle Cell Disease FREE TO VIEW

Rajaa Alsaggaf; Siraj Wali; Faten Alsayis; Sara Batawi; Lana Mukharesh; Ghadah Batawi
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Sleep Medicine and Research Center, King Abdulaziz University Hospital, Jeddah, Saudi Arabia

Chest. 2015;148(4_MeetingAbstracts):1059A. doi:10.1378/chest.2272026
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SESSION TITLE: Sleep Disorders Posters II: Consequences of OSA and Treatment

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 28, 2015 at 01:30 PM - 02:30 PM

PURPOSE: The purpose of this study is to determine the prevalence of restless legs syndrome (RLS) among adult patients with sickle cell disease (SCD) and compare it to non-SCD anemia patients.

METHODS: This is a cross sectional study that was conducted from December 2013 - July 2014. Data was collected from patients attending the Hematology Clinics at King Abdulaziz University Hospital. Patients were of two groups; SCD and non-SCD anemia. Patients with secondary RLS, including that resulting from iron deficiency anemia, were excluded. All patients were individually interviewed and data was collected on the following: demographic features, clinical features, laboratory tests, the International Restless Leg Syndrome Study Group Criteria (IRLSG), International Restless Leg Syndrome Rating Scale, and daytime sleepiness using Epworth Sleepiness Scale (ESS).

RESULTS: Eighty-nine patients were recruited, 44 of which were patients with SCD and 45 with other types of anemia. The two groups were comparable in age, gender, body mass index, smoking habit, and co-morbidities. The prevalence of RLS, severity of RLS and levels of daytime sleepiness were similar in both groups of patients, with no statistically significant differences. The prevalence of RLS among SCD patients and non-SCD anemia patients was 13.6% (6/44) and 8.8% (4/45) respectively, and the majority of patients had moderate to severe RLS. Daytime sleepiness was similar in both groups with the rate of excessive daytime sleepiness being 20.5 % and 17.8 % in SCD and non-SCD anemia groups respectively .

CONCLUSIONS: RLS is common in adult SCD patients, but as common as in other anemia patients. Moreover, its severity is similar in both groups. Based on previous epidemiological studies, the prevalence of RLS in SCD patients is similar to that in the general population.

CLINICAL IMPLICATIONS: SCD patients are not at a higher risk of RLS than other anemia patients. However, expanded research is needed to compare the prevalence of RLS between SCD patients and the general population, and to understand the implications of RLS on SCD patients’ health and quality of sleep.

DISCLOSURE: The following authors have nothing to disclose: Rajaa Alsaggaf, Siraj Wali, Faten Alsayis, Sara Batawi, Lana Mukharesh, Ghadah Batawi

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