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Critical Care |

Does the Mean Arterial Pressure Influence Mortality Rate in Patients With Acute Hypoxemic Respiratory Failure Under Mechanical Ventilation?

Wonil Choi, MD
Author and Funding Information

Keimyung University Dongsan Hospital, Daegu, Korea (the Republic of)


Chest. 2015;148(4_MeetingAbstracts):305A. doi:10.1378/chest.2270516
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Abstract

SESSION TITLE: Mechanical Ventilation and Respiratory Failure Posters

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 28, 2015 at 01:30 PM - 02:30 PM

PURPOSE: In sepsis patients, target mean arterial pressures (MAPs) greater than 65 mmHg are recommended. However, there is no such recommendation for patients receiving mechanical ventilation. We aimed to evaluate the influence of MAP over the first 24 hours after ICU admission on the mortality rate at 60 days post-admission in patients showing acute hypoxemic respiratory failure under mechanical ventilation.

METHODS: This prospective, multicenter study included 22 intensive care units and compared the mortality and clinical outcomes in patients showing acute hypoxemic respiratory failure with high (75-90 mmHg) and low (65-74.9 mmHg) MAPs over the first 24 hours of admission to the intensive care unit.

RESULTS: Of the 844 patients with acute hypoxemic respiratory failure, 338 had a sustained MAP of 65-90 mmHg over the first 24 hours of admission to the intensive care unit. At 60 days, the mortality rates in the low (26.2%) and high (24.5%) MAP groups were not significantly different. The intensive care unit days, hospital days, and 60-day mortality rate did not differ between the groups.

CONCLUSIONS: In the first 24 hours of ICU admission, mean arterial pressure range between 65 and 90mmHg in patients with acute hypoxemic respiratory failure under mechanical ventilation may not cause significantly differences in 60-day mortality.

CLINICAL IMPLICATIONS: Target mean arterial pressure would be range between 65 and 90mmHg in patients with acute hypoxemic respiratory failure under mechanical ventilation.

DISCLOSURE: The following authors have nothing to disclose: Wonil Choi

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