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Does Small Airway Obstruction in Pulmonary Function Tests Affect End-Expiratory CO Levels? FREE TO VIEW

Banu Salepci, MD; Ali Fidan, MD; Elif Torun Parmaksiz, MD; Esma Coskun; Nesrin Kiral, MD; Benan Caglayan, MD
Author and Funding Information

Dr. Lutfi Kirdar Kartal Training and Research Hospital Department of Chest Diseases, Istanbul, Turkey

Chest. 2015;148(4_MeetingAbstracts):1075A. doi:10.1378/chest.2270107
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SESSION TITLE: Tobacco Cessation and Prevention Posters

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 28, 2015 at 01:30 PM - 02:30 PM

PURPOSE: End-expiratory CO level, which is used to test smoking cessation is known to be effected by amount of cigarettes and time elapsed after last cigarette smoked. We aimed to evaluate effect of small airway obstruction (SAO) on end-expiratory carbon monoxide (eCO) levels.

METHODS: The study population consisted of cases who applied to smoking cessation clinic between April-December 2014. The duration of smoking(pack-years), pulmonary function tests (PFT) and eCO results were noted at first visit. The cases were questioned for last time of smoking and amount of cigarettes smoked within past 12 hours. Pearson’s correlation test was used to determine factors effecting eCO levels.

RESULTS: Mean age of 167 cases was 38.7±12.7. Of the cases, 112 were male (67.1%) and 55 were female(32.9%). Mean duration of smoking was 23.3±16.4 pack-years, mean eCO level was 14.1±6.9 ppm,mean FEF25-75% was 77.2±28.2. Mean period elapsed after last cigarette was 1.5±1.8 hours and mean number of cigarettes smoked within past 12 hours was 7.2±5.0. SAO was found in 50 cases(34.1%) Correlation analyses revealed that eCO levels were correlated positively to duration of smoking and amount of cigarettes they smoked within past 12 hours (p=0.03, r=0.228 and p<0.001, r=0.511, respectively) and negatively to the last time of smoking (p=0.023,r=-0.176). SAO in PFT was not correlated to eCO level (p>0.05).

CONCLUSIONS: End-expiratory CO level is closely related to duration of smoking, number of cigarettes smoked within past 12 hours and period elapsed after last cigarette. Presence of SAO does not seem to effect eCO levels.

CLINICAL IMPLICATIONS: End-expiratory CO level is related to duration and amount of smoking as expected, whereas presence of SAO does not effect eCO.

DISCLOSURE: The following authors have nothing to disclose: Banu Salepci, Ali Fidan, Elif Torun Parmaksiz, Esma Coskun, Nesrin Kiral, Benan Caglayan

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