Sleep Disorders |

Relation of Plasma Level of Hypoxanthine/Xanthine as Markers of Oxidative Stress: Relation With Different Stages of Obstructive Sleep Apnea Syndrome FREE TO VIEW

Harmanjit Hira, DM
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Maulana Azad Medical College and LN Hospital, New Delhi, India

Chest. 2015;148(4_MeetingAbstracts):1045A. doi:10.1378/chest.2269530
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SESSION TITLE: Sleep Disorders Posters I: Diagnosis

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 28, 2015 at 01:30 PM - 02:30 PM

PURPOSE: Evidence of increased plasma level of hypoxanthine/xanthine as a criterion of tissue hypoxia is available in literature. We anticipated that plasma levels of hypoxanthine/xanthine might be high due to oxidative stress among patients of obstructive sleep apnea syndrome (OSAS). Nobody studied this relationship earlier. The purpose of this study was to determine plasma level of hypoxanthine/xanthine in patients of OSAS and to find the relation with severity of OSAS.

METHODS: It was a case control study. All participants underwent biochemical and polysomnographic examinations. Forty three patients of OSAS were included in study. The control group without OSAS comprised of 43 subjects. Severity of OSAS was determined on basis of apnea-hypopnea index (AHI). Severity of disease was found to be severe in 34 and moderate in nine patients. Plasma level of xanthine/hypoxanthine was measured by fluorometric analysis. This method measured both hypoxanthine and xanthine as a single reading; therefore term hypoxanthine/xanthine was used in this study. Data collected was analyzed by applying suitable statistical methods.

RESULTS: In patients of OSAS, mean plasma level of hypoxanthine/xanthine was 5.38 ± 5.11, µM/L and in controls it was 1.23 ± 0.42 µM/L (Standard laboratory reference range from 0.70 to 1.70 µM/L). Statistically significant difference was found between both groups (p value 0.001). Positive correlation between xanthine/hypoxanthine levels and severity of OSAS was found. Levels of hypoxanthine/xanthine were correlated with age and serum triglyceride value, and it was found to be positive. Joint explanatory power of these significant factors was found to be 59.6% (p-value < 0.001).

CONCLUSIONS: Plasma levels of hypoxanthine/xanthine (oxidative stress markers) increased in blood of OSAS patients to a variable degree depending on the severity of the disease. A positive correlation between hypoxanthine/xanthine levels and age and serum triglyceride levels was present.

CLINICAL IMPLICATIONS: Measurement of oxidative stress markers in OSAS may be suitable for clinical follow-up to know the efficacy of treatment.

DISCLOSURE: The following authors have nothing to disclose: Harmanjit Hira

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