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Pulmonary Vascular Disease |

Diabetes Mellitus and Functional Capacity in Pulmonary Arterial Hypertension

Julianne Nichols, DO; Raymond Foley, DO; Diahann Wilcox, APRN-BC; Debapriya Datta, MD
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University of CT Health Ctr, Farmington, CT


Chest. 2015;148(4_MeetingAbstracts):957A. doi:10.1378/chest.2269319
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Abstract

SESSION TITLE: Pulmonary Arterial Hypertension Posters II

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 28, 2015 at 01:30 PM - 02:30 PM

PURPOSE: Diabetes mellitus (DM) has been reported to be present in 12% of patients with PAH. Limited information exists on impact of DM on functional status. Whether DM affects functional status in patients with PAH is not known. The objective of this study was to determine the impact of DM on functional status in patients with PAH.

METHODS: The medical records of 74 patients with PAH, defined as mean pulmonary artery pressure (mPAP) ≥25mm Hg and mean pulmonary arterial wedge pressure ≤ 15mmHg, being treated at the Pulmonary Hypertension Center at our institution, over the last 6 years (2007 to 2013) were reviewed. The following data was obtained in these patients -age, gender, mPAP, mean pulmonary vascular resistance (PVR), and number of patients with DM. Functional status in PAH was assessed by 6MWD and NYHA class at initial evaluation. Impact of DM on 6MWD and NYHA class was determined by univariate analysis, using independent t-test as well as by using Pearson’s test for linear correlation.

RESULTS: Of 74 patients, 75% were female; mean age was 64 + 14 years. Mean mPAP for studied subjects was 42 + 13 mmHg; mean PVR was 573± 384 dynes/sec/cm5; mean 6MWD was 350 ±117 meters. NYHA class ranged from 1-4. DM was present in 10 patients (13.5%). NYHA class ranged from 1-3 in diabetics and 2-4 in nondiabetics (r=0.106, p=0.3; p by t-test=0.3). 6MWD was 367 ±128 meters in diabetics and 344 ± 117 m in non-diabetics ( t-test: p=0.6; r=1.06, p=p=0.5).

CONCLUSIONS: There was no significant difference in 6MWD and NYHA class between diabetic and non-diabetic patients with PAH. No significant correlation was noted between diabetes and 6MWD and NYHA class respectively.

CLINICAL IMPLICATIONS: Diabetes mellitus does not appear to affect functional status in PAH. More studies are needed to corroborate these findings.

DISCLOSURE: The following authors have nothing to disclose: Julianne Nichols, Raymond Foley, Diahann Wilcox, Debapriya Datta

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