Lung Cancer |

Elevated Levels of Pro-Cathepsin D in the Plasma and Pleural Fluid of Patients With Lung Cancer FREE TO VIEW

Chang Youl Lee, MD; Myung-Goo Lee, MD; In-Bum Suh
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Hallym Medical Center, Chuncheon, Korea (the Republic of)

Chest. 2015;148(4_MeetingAbstracts):560A. doi:10.1378/chest.2267700
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SESSION TITLE: Lung Cancer Screening & Diagnosis Posters

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 28, 2015 at 01:30 PM - 02:30 PM

PURPOSE: The proteolytic degradation of extracellular matrix components is a curtail part of the multistep process of cancer cell invasion and metastasis. Cathepsin D (CD) as a lysosomal aspartic protease is one of the most important intracellular enzymes considered to be substantially involved in tumor invasion. Procathespin D (pCD) is overexpressed and secreted by cells of various tumor types. It was the aim of this study to evaluate the serum and pleural fluid levels of CD and pCD as a differential diagnostic tool in patients with pleural effusion caused by malignant or benign process.

METHODS: CD, pCD were measured in plasma and pleural fluid samples obtained from 85 patients (40 patients with lung cancer, 30 patients with tuberculosis, 10 patients with parapneumonic effusion, 5 patients with transudate effusion) using an enzyme immunoassay(ELISA) and sandwich ELISA respectively.

RESULTS: Concentration of pleural CD was not significantly different in patients with malignant pleural effusion compared with non malignant effusion (mean 15.32 vs. 17.77 ng/ml; p > 0.05), and also the concentration of serum CD was not significantly different (mean 44.04 vs. 46.72 ng/ml; p > 0.05). Plasma pCD of malignant pleural effusion and non malignant effusion were 291 ng/ml and 219 ng/ml, respectively (p <0.05) and pleural pCD of malignant pleural effusion and non malignant effusion were 97.21 ng/ml and 30.63 ng/ml, respectively (p <0.05).

CONCLUSIONS: In this small cohort, the plasma and pleural pCD of lung cancer patients with malignant effusion showed elevated levels of pCD compared with CD. Further prospective multicenter studies might shed more light on the value of CD and pCD in the diagnostics of pleural effusion.

CLINICAL IMPLICATIONS: The plasma and pleural fluid levels of pCD could be a diagnostic marker of malignant effusion with lung cancer.

DISCLOSURE: The following authors have nothing to disclose: Chang Youl Lee, Myung-Goo Lee, In-Bum Suh

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