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Pulmonary Vascular Disease |

Cardiac Magnetic Resonance Imaging Assessment of Pulsatility May Not Be Significantly Altered Based on Body Surface Area, Body Mass Index, Gender, or Age FREE TO VIEW

Mohamad Zetir, MB; Jordan Ray, MD
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Mayo Clinic Florida, Oviedo, FL


Chest. 2015;148(4_MeetingAbstracts):946A. doi:10.1378/chest.2262582
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Abstract

SESSION TITLE: Pulmonary Arterial Hypertension Posters I

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 28, 2015 at 01:30 PM - 02:30 PM

PURPOSE: Cardiac Magnetic resonance imaging (CMR) may aid in assessment of pulmonary vascular remodeling in pulmonary arterial hypertension (PAH) patients, but the effect of age, gender or size on measurements of pulmonary artery (PA) size and indices of stiffness (e.g. pulsatility) are incompletely understood. Thus, the aim of this study is to assess these changes in a prospective cohort of PAH patients and normal controls.

METHODS: 79 subjects underwent same day CMR and right heart catheterization (RHC). On CMR, PA area and pulsatility ((PAmax-PAmin)/PAmin) were measured and age, gender, body mass index (BMI), and body surface area (BSA) were recorded. Student T test and Pearson’s correlation were used. P<0.05 was deemed significant.

RESULTS: PA pulsatility index was 0.28 +/- SD of 0.179. Mean age was 60.77 +/- SD of 15.9 and 61 (77%) subjects were female. There was no significant association for PA pulsatility index based on age, gender, BMI, or BSA (p>0.05 for all). Mean PA size was 9.60mm with a S/D of +/- 3.18. There was no significant association for mean PA size and BMI, or age. There was a positive correlation with BSA (R-value 0.355, P-Value 0.0013) and gender.

CONCLUSIONS: The use of CMR to assess pulmonary vascular remodeling and stiffness is an evolving and potentially helpful tool to characterize PAH patients. Although there was a positive correlation between mean PA size with body surface area and gender, the PA pulsatility index does not appear to be affected, and there appears to be no significant change in conventional parameters based on age, gender or PA size.

CLINICAL IMPLICATIONS: The use of cardiac magnetic resonance imaging (CMR) is an evolving tool that is being used in the evaluation of pulmonary artery hypertension. This study evaluated the effects and the relationship of PA size and pulsatility indices to age, gender, BMI, and BSA.

DISCLOSURE: The following authors have nothing to disclose: Mohamad Zetir, Jordan Ray

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