Pulmonary Procedures |

Efficacy of TB-PCR Using EBUS-TBNA Samples in Patients With Intrathoracic Granulomatous Lymphadenopathy FREE TO VIEW

Hae Jung Na, MD; Min Ki Lee; Jung Seop Eom; Seung Eon Song
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Pusan National University, Busan, Korea (the Republic of)

Chest. 2015;148(4_MeetingAbstracts):813A. doi:10.1378/chest.2258783
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SESSION TITLE: Interventional Pulmonology Posters I

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 28, 2015 at 01:30 PM - 02:30 PM

PURPOSE: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is used widely to diagnose intrathoracic granulomatous lymphadenopathy (IGL). Histological, microbiological, and molecular tests are the mainstay for diagnosing IGL, while there is little information on tuberculosis-polymerase chain reaction (TB-PCR) using EBUS-TBNA samples. This study describes the efficacy of TB-PCR using EBUS-TBNA samples in IGL patients.

METHODS: A retrospective study examining a prospectively collected database. The pathology was classified into five grades: I) granulomatous reaction with caseation; II) granulomatous reaction without caseation; III) necrosis; IV) non-specific; and V) inadequate.

RESULTS: Forty-two patients were diagnosed with IGL [15 tuberculous lymphadenitis (TBL), 27 sarcoidosis]. TB-PCR was performed in 37 patients (13 TBL, 24 sarcoidosis); 7 of the 13 TBL patients (54%) were TB-PCR positive. Of the seven patients whose histological results were non-diagnostic (grades IV and V), four were diagnosed with TBL based on a positive TB-PCR, preventing further invasive evaluations such as mediastinoscopy.

CONCLUSIONS: TB-PCR of EBUS-TBNA samples is useful for diagnosing IGL.

CLINICAL IMPLICATIONS: TB-PCR using EBUS-TBNA samples can be helpful in IGL patients.

DISCLOSURE: The following authors have nothing to disclose: Hae Jung Na, Min Ki Lee, Jung Seop Eom, Seung Eon Song

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