Obstructive Lung Diseases |

Neutrophil to Lymphocyte and Platelet to Lymphocyte Ratios as Novel Inflammatory Markers in Patients With Chronic Obstructive Pulmonary Disease FREE TO VIEW

Sezgi Sahin Duyar, MD; Yalcin Solak, MD; Dilek Tekis, MD; Jale Karakaya; Ferit Kuscu; Asuman Erarslan; Gulen Topaloglu
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Karaman State Hospital, Department of Pulmonology, Karaman, Turkey

Chest. 2015;148(4_MeetingAbstracts):688A. doi:10.1378/chest.2251279
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SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 28, 2015 at 01:30 PM - 02:30 PM

PURPOSE: Neutrophil to lymphocyte ratio(NLR) and platalet to lymphocyte ratio (PLR) are recently defined novel inflammatory markers which are readily available. Their prognostic signifigance has been shown for a number of inflammatory diseases. A recent study evaluated the role of NLR, but not PLR, in patients with chronic obstructive pulmonary disease (COPD). Thus, we aimed to investigate the correlation between NLR, PLR, C-reactive protein (CRP) and severity of COPD in patients who had stable disease and alteration of these markers during acute exacerbations.

METHODS: The clinical and dermographical charecteristics of 72 patients were reviewed retrospectively. Complete blood cell counts and differential and CRP values were recorded from electronic database of the hospital. NLR and PLR were calculated from absolute neutrophil and lymphocyte counts from CBC, respectively . There were 13 patients who had data available for both acute exacerbation and stable stage.

RESULTS: Neither NLR nor CRP showed any statistically significant correlation with the clinical parameters in stable COPD (p>0.05). PLR was elevated in high risk group of patients with severe airflow limitation (p=0.011). Median values of CRP levels and NLR were elevated in acute exacerbation compared with baseline values (p= 0.003, p=0.007, respecively).

CONCLUSIONS: The results of this study showed that PLR was correlated with severity of stable COPD in contrast to NLR. On the other hand, NLR was increased in patients with acute COPD exacerbation. Further studies are required to better elucidate the roles of these novel inflammatory markers.

CLINICAL IMPLICATIONS: In stable stage, PLR can be separated for defining COPD patients with high risk, whereas NLR and CRP can be used as markers for acute exacerbations in COPD. However, The number of the study cohort was lower and the study design was retrospective. Thus, causative inferences cannot be made based on our results. Despite these limitations the results are promising but must be further investigated in a prospective study.

DISCLOSURE: The following authors have nothing to disclose: Sezgi Sahin Duyar, Yalcin Solak, Dilek Tekis, Jale Karakaya, Ferit Kuscu, Asuman Erarslan, Gulen Topaloglu

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