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Pediatrics |

Value of Screening Spirometry for Early Diagnosis of Bronchiolitis Obliterans in Children After Allogeneic Hematopoietic Stem Cell Transplantation

Jong-seo Yoon, MD
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the Catholic University of Korea, Seoul, Korea (the Republic of)


Chest. 2015;148(4_MeetingAbstracts):784A. doi:10.1378/chest.2249484
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Abstract

SESSION TITLE: Pediatrics Posters

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 28, 2015 at 01:30 PM - 02:30 PM

PURPOSE: Bronchiolitis obliterans (BO) is chronic graft versus host disease occurring in the lung. Serial secreening spirometry is recommended after transplantation for early diagnosis of BO. However, little is known about the value of such serial spirometry, and the optimum methods.

METHODS: One hundred and eleven consecutive patients aged 6 or more years at the time of transplantation who underwent allogeneic HSCT were recruited. Screening spirometries were done 1 week before transplantation, and 3, 6, 9, and 12 months after transplantation. When findings of obstructive lung disease were shown from the spirometry, chest high resolution computed tomography was performed.

RESULTS: Of the 111 patients, fives (4.3%) developed BO. Of the 5 patients who developed BO, two patients could be diagnosed early through screening spirometry. This screening spirometry did not help the early diagnosis of BO in the other 3 patients because BO developed after 12 months of transplantation, which is after our screening time period.

CONCLUSIONS: In conclusion, 3 monthly PFT to 12 months after transplantation in patients who underwent allogeneic HSCT helped make early diagnosis of BO, but there are limitations.

CLINICAL IMPLICATIONS: Future studies will add to the development of a new protocol to be evaluated.

DISCLOSURE: The following authors have nothing to disclose: Jong-seo Yoon

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